范冰冰的绯闻韩国延世大学基本概况【2】
学校名称： 韩国延世大学 연세대학교
所在位置：韩国，首尔市西大门区延世路50号
学费：42000 人民币
录取率：0.501
1.杰出研究成果展示有关梅花的古诗
Location Matters: Local gene expression in neural circuits explained
英雄联盟自动关闭College of Medicine Professor Hosung Jung and his team have uncovered the function of local mRNA translation in the formation and maintenance of neural circuits. Neurons make long-distance connections via their axons, which need a number of different proteins. The problem is that DNA, the blueprint to make proteins, resides in the neuronal cell body, which is often remote from the axon terminal. How proteins needed at the axon terminal are
supplied in a timely manner has remained a puzzle. One idea, which was confirmed in this research, was that the neuron transcribes messenger RNAs (mRNAs) from its DNA in the cell body, transport them in a translationally repressed form to the axon terminal, and synthetize specific proteins when and where they are needed by local mRNA translation.To test this hypothesis, they developed a new technique called axon-TRAP (translating ribosome affinity purification), which allows isolation of mRNAs being translated into proteins at the axon terminal in mouse in vivo. Using this technique, they discovered that specific mRNAs are locally translated into proteins necessary for making (or pruning) connections (or synapses) as the neural circuity is being built. An unexpected finding was that axonal local mRNA translation continues in the mature nervous system, where it is used to make proteins necessary for axon survival. The research could have important applications for the understanding of neurodegenerative disorders, which often result from failure to maintain axonal integrity. According to Professor Jung: “Although a strong genetic link has been found between the mutations in the RNA-binding proteins (RBPs) and neurodegenerative disorders like amyotrophic lateral sclerosis (ALS) in huma
n genetics, mechanistic details to explain this link was lacking. Because RBPs regulate mRNA splicing, transport and translation, this research enables us to view the cause of neurodegenerative diseases from a new perspective: dysfunctional RBPs prevent local translation of axon survival proteins.”Joining Professor Jung were two of his graduate students, Jane Jung and Jiyeon Ohk, and Professor Christine Holt’s research team of University of Cambridge. Their findings were published June 30 in Cell under the title “Dynamic Axonal Translation in Developing and Mature Visual Circuits.”
研究成果一：位置问题，局部基因以神经回路的方式表达出来
医学院教授郝荣荣博士及其团队发现了神经回路形成和维持中局部mRNA译码的功能。神经元通过其轴突进行长距离连接，需要许多不同的蛋白质。问题是，DNA是制造蛋白质的蓝图，它驻留在通常远离轴突末端的神经元细胞体内。如何及时提供轴突末端蛋白质所需的蛋白质仍然是一个难题。在这项研究中证实的一个想法是，神经元从细胞体中的DNA转录信使RNA(mRNA)，将它们以译码抑制形式转运到轴突末端，并且在需要时和在何处合成特异性蛋白质通过局部mRNA译码。为了测试这个假设，他们开发了一种称为轴突-TRA
P(译码核糖体亲和纯化)的新技术，其允许分离在体内小鼠轴突末端转化成蛋白质的mRNA。使用这种技术，他们发现特定的mRNA被局部译码成正在构建(或修剪)连接(或突触)所必需的蛋白质。意想不到的发现是在成熟神经系统中继续轴突局部mRNA译码，其中它用于制备轴突存活所必需的蛋白质。该研究可能有重要的应用，以了解神经退行性疾病，这往往是由于维持轴突完整性的失败。据Jung教授介绍：“虽然人类遗传学中RNA结合蛋白(RBPs)和神经变性疾病如肌萎缩性侧索硬化(ALS)的突变之间已经发现了强大的遗传连锁，但缺乏解释这一联系的机制细节。因为RBP调节mRNA剪接，转运和译码，这项研究使我们从一个新的角度来看待神经退行性疾病的原因：功能障碍的RBPs阻止轴突存活蛋白的局部译码。加入Jung教授的两位研究生Jane Jung和Jiyeon Ohk，以及Christine Holt教授的剑桥大学研究团队
Developing and Mature Visual Circuits”。党员自我评价范文
Currently, there are fears that North Korea could soon test a hydrogen bomb. Amidst these concerns, Yonsei Earth System Sciences Professor Hong Tae-Kyung and his team are studying how North Korea’s nuclear tests could affect seismic activities at Mount Bae
kdu. This is the first study to show that seismic waves following a nuclear test could possibly cause an earthquake and volcanic eruption at the mountain on the North Korean-Chinese border.Professor Hong and his team examined the dynamic stress changes of the magma chamber of Mt. Baekdu that can be induced by hypothetical North Korean nuclear explosions. Seismic waveforms for hypothetical underground nuclear explosions at North Korean test site were calculated by using an empirical Green’s function approach based on the seismic waveforms of North Korea’s first three nuclear tests; such a technique is efficient for regions containing poorly constrained velocity structures. The peak ground motions around the volcano were estimated from empirical strong-motion attenuation curves. A hypothetical M7.0 North Korean underground nuclear explosion may produce peak ground accelerations of 0.1684 m/s2 in the horizontal direction and 0.0917 m/s2 in the vertical direction around the volcano, inducing peak dynamic stress change of 67 kPa on the volcano surface and ~120 kPa in the spherical magma chamber. North Korean underground nuclear explosions with magnitudes of 5.0–7.6 may induce overpressure in the magma chamber of several tens to hundreds of kilop
ascals.Their calculations show that with a magnitude of 7.0, the blast would cause seismic tremors and changes in seismic earth pressure on the surface of Mount Baekdu and inside its magma chamber. This is the first study to show that North Korea’s nuclear tests are capable of causing significant volcanic activity at Mount Baekdu. The results were published on February 17 in the online edition of Scientific Reports, a sister journal of Nature.
研究成果二：朝鲜核试验可能引发白头山火山爆发。租房子要注意什么
目前，有人担心朝鲜可能很快就会测试。在这些担忧之中，延世大学地球系统科学院教授洪泰炯及其团队正在研究朝鲜的核试验如何影响白百山的地震活动。这是第一个研究表明，核试验后的地震波可能导致北韩和中国边界山区发生地震和火山爆发。洪教授及其团队研究了山岩浆室的动态压力变化。可以通过假想的朝鲜核爆炸诱发的白皮书。基于北朝鲜首个三次核试验的地震波形，利用经验Green函数法计算了朝鲜试验地点假想地下核爆炸的地震波形。这种技术对于具有受限制的速度结构的区域是有效的。根据经验强运动衰减曲线估计火山周围的地面高峰运动。假设的M7.0北韩地下核爆炸可能会在水平方向产
生0.1684 m / s 2的峰值地面加速度，0.0917 m / s 2在火山周围的垂直方向上，在火山表面引起了67 kPa的峰值动态应力变化，球形岩浆室引起了〜120 kPa。北韩地下核爆炸的爆震数值为5.0-7.6，可能会导致岩浆室超压几十到几百千帕斯卡。他们的计算表明，在7.0级时， 爆炸将造成地震震颤和Baekdu山表面及其岩浆室内的地球地球压力变化。这是第一个研究表明，朝鲜的核试验能够在白百山开展重大的火山活动。研究结果于2月17日在“Nature”杂志在线版发表。
Identification and Characterization of Small Molecules that Suppresses Growth of Cancers via Degrading both b-catenin and Ras
A research team led by Professors Kang Yell Choi in the Yonsei’s Department of Biotechnology has identified small molecules that inhibit growth of colorectal cancer (CRC) cells via degrading both b-catenin and Ras. The small molecules inhibiting the Wnt/b-catenin pathway were selected by screening of several small-molecule libraries. Among the 40 compounds initially identified by their inhibitory effects on the Wnt/b-catenin pathway reporter activity, KY1220 was selected as a compound that efficiently de
grades both b-catenin and Ras without showing cytotoxicity. KY1220 effectively inhibited transformation of CRC cells with activated Wnt/b-catenin and Ras/ERK pathways by adenomatos polyposis coli (APC) and K-Ras mutations. By collaboration with Professor Gyoonhee Han from the Department of Biotechnology and Pharmacology, several hundreds of derivatives were obtained, and KYA1797K, a functionally improved compound retaining druggablity, was obtained.KYA1797K effectively suppresses the growth of CRC cells with activated Wnt/β-catenin and Ras/ERK pathways. The RGS domain of axin was identified as a target for KYA1797K and molecular structure of RGS-axin-KYA1797K was determined by collaboration with Professor Weontae Lee in the Department of Biochemistry.They further characterized that KYA1797K activates GSK3β by modulation of the b-catenin destruction complex. The activated GSK3β induces phosphorylation of both b-catenin and Ras, which is required for their polyubiquitin-dependent proteasomal degradation, via recruitment of theb-TrCP E3 linker protein. KYA1797K effectively suppressed growth of CRC in the xenograft mice transplanted with the CRC cells harboring both APC and K-Ras mutations. The effectiveness of KYA1797K
你的样子罗大佑was further shown by using the genetically engineered Apcmin/+/KrasG12DLA2 mice harboring both APC and K-Ras mutations.Their findings were published June 14, 2016 in the online edition of Nature Chemical Biology (1st author; Pu-Hyeon Cha). The title of the article is “Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation.” This study suggests that destabilization of both β-catenin and Ras via targeting axin is a potential therapeutic strategy for treatment of CRC and other types of cancers activated Wnt/β-catenin and Ras pathways.