临床神经外科杂志2020年第17卷第3期287 DOI：10.3969/j.ien-1672L770.2020-03.010•论著Ki-67表达及MRI信号值与颅底脊索瘤术后
复发的相关性
王科，谢思宁，霍续磊，王亮，吴震，杜江，张俊廷
!摘要】目的探讨颅底脊索瘤K1L7表达及MRI信号值与颅底脊索瘤复发的相关性。方法回顾性
析其K1L7指数、MRI影像学特点，随访观察患者的预后，进行统计学分析’结果本组患者的K1L7表达指
数为1%〜30%，平均值为7.6%±8.0%'其中，Ki-67指数<5%(K1组)、5%〜15%(K2组)及>15%(K3
组)的患者，分别为12例(42.9%)、12例(42.9%)和4例(14.3%)。脊索瘤与脑干的MRI信号值比值,R o&
R o、Re n的范围分别为0.41〜1.05、1.3〜4.4、0.7〜2.3。其中MRI分组组(患者12例、组*患者16例，无组
I的患者’Spearman相关分析显示,MRI信号值与Ki-67指数分组之间无相关关系#Y二0.553)。患者术后平
均随访(35.5±23.8)个月(3〜86个月)，其中复发患者19例(67.9%)，平均复发时间(27.4±19.6)个月'
相关分析显示,MRI信号值组*患者的复发率明显高于组II(Y二0.012)o多因素生存分析显示，脊索瘤的
K-67指数#Y二0.004)和MRI信号值(Y二0.013)是颅底脊索瘤术后复发的危险因素’结论颅底脊索瘤的
Ki-67表达指数与MRI信号值是其术后复发的预测指标；并且均为独立危险因素’
!关键词】颅底脊索瘤；Ki-67；MRI；复发
!中图分类号】R739.41【文献标志码】A【文章编号】1672-7770(2020)03-0287-05
Research on relations among Ki-67,MRI grade and reccrreecc of skull base choriomas
WANG Ke,XIE Si-zing,HUO XuHei,et al Department o Neurosurgerg,Beping Tiantan Hospital,
Capital Medial University,Beping100070,China
Corresponding authors：ZHANG Jun-Hng,DU Jiang
Abstract:Objective Tv evvluaiv tha eyeci of Ki-67and MRI gradv on recurrence of skul l
bass chordomas.MetUods Tha clinical dato of28patients with skull bass chordoma confined by pathomae undeoent surgical resection at depaeoeni of N—osuo/O,Beijing Tiantan Hospital,
Capital Medical Uni v arsity%were analyzed retrospectivvie-Tha iemunohistochemisto study of Ki-
杜江67%MRI gradv%as well as tha clinical dato were also analyzed and dll tha patients were followed-
up.SPSS was used fas statistical peOoonanca-Resklts Thera were28skull bass chordomas
included in tha poseni study,tha expression of Ki-67vvOed from1%-30%(fig2)%tha men
expression rata was7.6%±8.0%%there were12(42.9%)%12(42.9%)%and4(14.3%)in
goup K1%K2and K3%respec/veie-MRI signal rate of tha tumas to brainstem on T[%T?and Ten
wera(0-41-1.05)%(1.3-4.4)%(0.7-2.3)respectivvie%and there was nv goup1in tha
present seOvs by MRI goup%there was12casvs in goup2and16casvs in goup3-Tha spyman relationship analysis showed nv correlational relationship betoeen tha MRI signal gradv and Ki-67
expression(Y二0.553)-With a men follow up tiev of35.5±23.8months(3-86months)%there
were19casvs had recurrence(67-9%)%with tha men recurrence Oev27-4土19-6months%MRI
signal goup3showed woes recuirenca rate was than tha goup2(Y二0.012)-Tha COX analysis
showed tha expression of Ki-67indev(Y=0.004)%MRI signal gradv(Y=0.013)was tha Osk
基金项目：国家自然科学基金(81672506)(首都医科大学校自然基金(PYZ19105)(首都
医科大学附属北京天坛医院院自然基金(YZR-2020-06)
作者单位:100070北京，首都医科大学附属北京天坛医院神经外科(王科，霍续磊，王亮，
吴震，张俊廷)，麻醉科(谢思宁)(北京市神经外科研究所(杜江)
通信作者：张俊廷，杜江
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